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Atypical Parkinsonian (AT)

Atypical Parkinsonism (AT) syndromes are a group of progressive neurodegenerative disorders that are one of the leading causes of fatality and dementia in the elderly. Progressive supranuclear palsy (PSP), Multiple system atrophy (MSA), Corticobasal degeneration (CBD), Normal pressure hydrocephalus (NPH) and other overlap syndromes are the significant types of these AT. Globally the understanding and managing these disorder remains challenge. In this longitudinal study, we are prospectively recruiting a large cohort of patients with AT and thoroughly characterizing them by detailed clinical phenotyping. We perform clinical assessment, genetic evaluation, neuroimaging using advanced MRI techniques, biological sampling for biomarker testing, sleep studies (PSG), Optical coherence tomography (OCT), and cell based studies (IPSCs). In this ATPARK study patients will then be followed up and periodic assessments for the previously recorded parameters at baseline and at least one or two times over the next 3 years up to a maximum till the study duration. This data will be used to identify patterns and changes and help us prepare disease-specific models for phenotype, genetics, biomarker, and neuroimaging. This unique native dataset on atypical parkinsonism disorders will provide a better understanding of risks and demography and advance information on biomarkers.